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U-74389G

Cayman Chemical Item Number 75860

Methylated Tirilazad (CAS 153190-29-5)

U-74389G (CAS 153190-29-5)

See more	Antioxidants (63) Oxidative Injury (291)

Description

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.^1,2,3,4

1 Ishizaki, N., Zhu, Y., Zhang, S., et al. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation 63 202-208 (1997).

2 Palma-Vargas, J.M., Toledo, A.H., García-Criado, F.J., et al. 21-Aminosteroids block neutrophil infiltration and provide liver protection independent of nitrite/nitrate levels. J Surg Res 66 131-137 (1996).

3 Perna, A.M., Liguori, P., Bonacchi, M., et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res 34 25-31 (1996).

4 Shoskes, D.A., Xie, Y., and Gonzalez-Cadavid, N.F. Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat. Implications for renal transplantation. Transplantation 63 495-500 (1997).

Synonyms	Methylated Tirilazad
Formal Name	21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-pregna-1,4,9(11)-triene-3,20-dione maleate salt
CAS Number	153190-29-5
Molecular Formula	C₃₈H₅₂N₆O₂ · C₄H₄O₄
Formula Weight	740.9
Formulation	A crystalline solid
Purity	>99%
λ_max	237, 287 nm
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=CC(N5CCCC5)=NC(N6CCCCC6)=N4)CC3)=O)([H])[C@](C7=CC1)([H])CCC([C@]7(C)C=C8)=CC8=O.OC(/C=C\C(O)=O)=O

Background Reading

Ishizaki, N., Zhu, Y., Zhang, S., et al. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation 63 202-208 (1997).

Perna, A.M., Liguori, P., Bonacchi, M., et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res 34 25-31 (1996).

Palma-Vargas, J.M., Toledo, A.H., García-Criado, F.J., et al. 21-Aminosteroids block neutrophil infiltration and provide liver protection independent of nitrite/nitrate levels. J Surg Res 66 131-137 (1996).

Shoskes, D.A., Xie, Y., and Gonzalez-Cadavid, N.F. Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat. Implications for renal transplantation. Transplantation 63 495-500 (1997).

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U-74389G is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing
500 mg	See a distributor in your region for pricing

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