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(−)-(α)-Kainic Acid

Cayman Chemical Item Number 78050

(CAS 487-79-6)

(-)-(α)-Kainic Acid (CAS 487-79-6)

See more	Neuroscience (725)

Description

Kainic acid is a natural marine product originally isolated from the red marine alga D. Simplex. It is a potent central nervous system stimulant, and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice.¹ Kainic acid is neuroexcitotoxic and epileptogenic, acting through specific kainate receptors.²

1 Marsicano, G., Goodenough, S., Monory, K., et al. CB₁ cannabinoid receptors and on-demand defense against excitotoxicity. Science 302 84-88 (2003).

2 Ferkany, J.W., Zaczek, R., and Coyle, J.T. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298(19) 757-759 (1982).

Formal Name	2S-carboxy-4S-(1-methylethenyl)-3S-pyrroldineacetic acid
CAS Number	487-79-6
Molecular Formula	C₁₀H₁₅NO₄
Formula Weight	213.2
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	Room temperature
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard [H]N1C[C@H](C(C)=C)[C@H](CC(O)=O)[C@H]1C(O)=O

Background Reading

Marsicano, G., Goodenough, S., Monory, K., et al. CB₁ cannabinoid receptors and on-demand defense against excitotoxicity. Science 302 84-88 (2003).

Ferkany, J.W., Zaczek, R., and Coyle, J.T. Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. Nature 298(19) 757-759 (1982).

(-)-(α)-Kainic Acid is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
25 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing

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