See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

L-NMMA (citrate)

Cayman Chemical Item Number 80200

L-NG-monomethyl Arginine citrate

L-NMMA (citrate)

See more

Description

L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared.1 The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.2,3

1 Griffith, O.W., and Kilbourn, R.G. Nitric oxide synthase inhibitors: Amino acids. Methods Enzymol 268 375-392 (1996).

2 Frey, C., Narayanan, K., McMillan, K., et al. L-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem 269 26083-26091 (1994).

3 Garvey, E.P., Tuttle, J.V., Covington, K., et al. Purification and characterization of the constitutive nitric oxide synthase from human placenta. Arch Biochem Biophys 311 235-241 (1994).

Synonyms
  • L-NG-monomethyl Arginine citrate
Formal Name N5-​[imino(methylamino)methyl]-​L-​ornithine,​ citrate
Molecular Formula 3[C7H16N4O2] · C6H8O7
Formula Weight 756.8
Formulation A crystalline solid
Purity ≥99%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CN([H]​)​/C(N([H]​)​CCC[C@@H]​(C(O)​=O)​N)​=N/[H]​.OC(CC(O)​=O)​(C(O)​=O)​CC(O)​=O

Background Reading

Rees, D.D., Palmer, R.M.J., Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 746-752 (1990).

Olken, N.M., Rusche, K.M., Richards, M.K., et al. Inactivation of macrophage nitric oxide synthase activity by NG-methyl-L-arginine. Biochem Biophys Res Commun 177 828-833 (1991).

Olken, N.M., and Marletta, M.A. N G-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase. Biochemistry 32 9677-9685 (1993).

Frey, C., Narayanan, K., McMillan, K., et al. L-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem 269 26083-26091 (1994).

Griffith, O.W., and Kilbourn, R.G. Nitric oxide synthase inhibitors: Amino acids. Methods Enzymol 268 375-392 (1996).

Garvey, E.P., Tuttle, J.V., Covington, K., et al. Purification and characterization of the constitutive nitric oxide synthase from human placenta. Arch Biochem Biophys 311 235-241 (1994).

Show all 6 Hide all but first 3
Size Global Purchasing
10 mg See a distributor in your region for pricing
25 mg See a distributor in your region for pricing
50 mg See a distributor in your region for pricing
100 mg See a distributor in your region for pricing

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

7-Nitroindazole
Aminoguanidine (hydrochloride)
BEC
eNOS (bovine recombinant)
L-NMMA (acetate)
NG-amino-L-Arginine (hydrochloride)
nNOS (rat recombinant)
nNOS (rat recombinant) - Purified
Show all 8 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?