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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

L-NMMA (citrate)

Cayman Chemical Item Number 80200

L-NG-monomethyl Arginine citrate

L-NMMA (citrate)

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Description

L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared.1 The Ki values for nNOS (rat), eNOS (human), and iNOS (murine) are approximately 0.18, 0.4, and 6 µM, respectively.2,3

1 Griffith, O.W., and Kilbourn, R.G. Nitric oxide synthase inhibitors: Amino acids. Methods Enzymol 268 375-392 (1996).

2 Frey, C., Narayanan, K., McMillan, K., et al. L-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem 269 26083-26091 (1994).

3 Garvey, E.P., Tuttle, J.V., Covington, K., et al. Purification and characterization of the constitutive nitric oxide synthase from human placenta. Arch Biochem Biophys 311 235-241 (1994).

Synonyms
  • L-NG-monomethyl Arginine citrate
Formal Name N5-​[imino(methylamino)methyl]-​L-​ornithine,​ citrate
Molecular Formula 3[C7H16N4O2] · C6H8O7
Formula Weight 756.8
Formulation A crystalline solid
Purity >99%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CN([H]​)​/C(N([H]​)​CCC[C@@H]​(C(O)​=O)​N)​=N/[H]​.OC(CC(O)​=O)​(C(O)​=O)​CC(O)​=O

Background Reading

Rees, D.D., Palmer, R.M.J., Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 746-752 (1990).

Olken, N.M., Rusche, K.M., Richards, M.K., et al. Inactivation of macrophage nitric oxide synthase activity by NG-methyl-L-arginine. Biochem Biophys Res Commun 177 828-833 (1991).

Olken, N.M., and Marletta, M.A. N G-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase. Biochemistry 32 9677-9685 (1993).

Frey, C., Narayanan, K., McMillan, K., et al. L-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem 269 26083-26091 (1994).

Griffith, O.W., and Kilbourn, R.G. Nitric oxide synthase inhibitors: Amino acids. Methods Enzymol 268 375-392 (1996).

Garvey, E.P., Tuttle, J.V., Covington, K., et al. Purification and characterization of the constitutive nitric oxide synthase from human placenta. Arch Biochem Biophys 311 235-241 (1994).

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Size Price Quantity Subtotal
10 mg $28.00 $0.00
25 mg $67.00 $0.00
50 mg $126.00 $0.00
100 mg $224.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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nNOS (rat recombinant) - Purified
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