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NG,NG-dimethyl-L-Arginine (hydrochloride)

Cayman Chemical Item Number 80230

ADMA (CAS 220805-22-1)

NG,NG-dimethyl-L-Arginine (hydrochloride) (CAS 220805-22-1)

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Description

NG,NG-dimethyl-L-Arginine (ADMA) is an endogenous nitric oxide synthase inhibitor. ADMA concentrations increase in several disease states including renal failure, muscular dystrophy, hypercholesterolemia, and pregnancy with preeclampsia, but its precise role in these diseases has not been elucidated.1,2,3,4

1 Vallance, P., Leone, A., Calver, A., et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339 572-575 (1992).

2 Matsuoka, H., Itoh, S., Kimoto, M., et al. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 29 242-247 (1997).

3 Jin, J., and D'Alecy, L.G. Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor. J Cardiovasc Pharmacol 28 439-446 (1996).

4 Holden, D.P., Fickling, S.A., Whitley, G.S.J., et al. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol 178 551-556 (1998).

Synonyms
  • ADMA
Formal Name N5-​[(dimethylamino)iminomethyl]-​L-​ornithine,​ dihydrochloride
CAS Number 220805-22-1
Molecular Formula C8H18N4O2 · 2HCl
Formula Weight 275.2
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​[C@@H]​(N)​CCCNC(=N)​N(C)​C

Background Reading

Vallance, P., Leone, A., Calver, A., et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339 572-575 (1992).

Holden, D.P., Fickling, S.A., Whitley, G.S.J., et al. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol 178 551-556 (1998).

Matsuoka, H., Itoh, S., Kimoto, M., et al. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension 29 242-247 (1997).

Jin, J., and D'Alecy, L.G. Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor. J Cardiovasc Pharmacol 28 439-446 (1996).

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