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L-hydroxy Arginine Acetate

Cayman Chemical Item Number 80300

L-NG-hydroxy Arginine Acetate (CAS 53598-01-9)

L-hydroxy Arginine Acetate (CAS 53598-01-9)

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Description

L-hydroxy Arginine is an intermediate in the oxidation of arginine to citrulline and NO by NOS. It also serves as an alternate substrate for the enzyme.1,2

1 Pufahl, R.A., Nanjappan, P.G., Woodard, R.W., et al. Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages. Biochemistry 31 6822-6828 (1992).

2 Campost, K.L., Giovanelli, J., and Kaufman, S. Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide. J Biol Chem 270 1721-1728 (1995).

Synonyms
  • L-NG-hydroxy Arginine Acetate
Formal Name N5-​[(hydroxyamino)iminomethyl]-​L-​ornithine,​ acetate
CAS Number 53598-01-9
Molecular Formula C6H15N4O3 · C2H3O2
Formula Weight 250.3
Formulation A crystalline solid
Purity >99%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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ONC(=N)​NCCC[C@H]​([NH3+]​)​C(=O)​O.[O-]​C(=O)​C

Background Reading

Feldman, P.L. Synthesis of the putative L-arginine metabolite L-NG-hydroxyarginine. Tetrahedron Lett 32 875-878 (1991).

Pufahl, R.A., Nanjappan, P.G., Woodard, R.W., et al. Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages. Biochemistry 31 6822-6828 (1992).

Campost, K.L., Giovanelli, J., and Kaufman, S. Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide. J Biol Chem 270 1721-1728 (1995).
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