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L-NIO (hydrochloride)

Cayman Chemical Item Number 80320

(CAS 36889-13-1)

L-NIO (hydrochloride) (CAS 36889-13-1)

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Description

L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 µM, respectively.1 L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.2

1 Babu, B.R., and Griffith, O.W. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).

2 Rees, D.D., Palmer, R.M.J., Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 746-752 (1990).

Formal Name N5-​(1-​iminoethyl)-​L-​ornithine,​ dihydrochloride
CAS Number 36889-13-1
Molecular Formula C7H15N3O2 · 2HCl
Formula Weight 246.1
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(=N)​NCCC[C@H]​(N)​C(=O)​O

Background Reading

Rees, D.D., Palmer, R.M.J., Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 746-752 (1990).

Babu, B.R., and Griffith, O.W. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).
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Related Products

7-Nitroindazole
NG-amino-L-Arginine (hydrochloride)
Vinyl-L-NIO (hydrochloride)

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