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L-NIO (hydrochloride)

Cayman Chemical Item Number 80320

(CAS 36889-13-1)

L-NIO (hydrochloride) (CAS 36889-13-1)

See more	Inhibitors (493) Nitric Oxide (101)

Description

L-NIO is a non-selective inhibitor of all NOS isoforms. The K_i values for nNOS (rat), eNOS (bovine), and iNOS (murine) are 1.7, 3.9, and 3.9 µM, respectively.¹ L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.²

1 Babu, B.R., and Griffith, O.W. N⁵-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).

2 Rees, D.D., Palmer, R.M.J., Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 746-752 (1990).

Formal Name	N5-(1-iminoethyl)-L-ornithine, dihydrochloride
CAS Number	36889-13-1
Molecular Formula	C₇H₁₅N₃O₂ · 2HCl
Formula Weight	246.1
Formulation	A crystalline solid
Purity	>95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC(=N)NCCC[C@H](N)C(=O)O

Background Reading

Rees, D.D., Palmer, R.M.J., Schulz, R., et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 746-752 (1990).

Babu, B.R., and Griffith, O.W. N⁵-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem 273 8882-8889 (1998).

Size	Price	Quantity	Subtotal
5 mg	$12.00		$0.00
10 mg	$23.00		$0.00
50 mg	$96.00		$0.00
100 mg	$168.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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