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L-Thiocitrulline (hydrochloride)

Cayman Chemical Item Number 80580

(CAS 212051-53-1)

L-Thiocitrulline (hydrochloride) (CAS 212051-53-1)

See more	Nitric Oxide (101)

Description

L-Thiocitrulline is a competitive inhibitor of nitric oxide synthase. The K_i values for the neuronal (rat) and inducible (rat aortic smooth muscle) isoforms of nitric oxide synthase were found to be 0.06 µM and 3.6 µM, respectively.¹ The IC₅₀ value for inhibition of aortic ring relaxation is approximately 25 µM.¹

1 Frey, C., Narayanan, K., McMillan, K., et al. L-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem 269 26083-26091 (1994).

Formal Name	N5-(aminothioxomethyl)-L-ornithine (dihydrochloride)
CAS Number	212051-53-1
Molecular Formula	C₆H₁₃N₃O₂S · 2HCl
Formula Weight	264.2
Formulation	A crystalline solid
Purity	>98%
λ_max	243 nm
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard NC(N([H])CCC[C@H](N)C(O)=O)=S.[·2HCl]

Background Reading

Frey, C., Narayanan, K., McMillan, K., et al. L-Thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem 269 26083-26091 (1994).

L-Thiocitrulline (hydrochloride) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing
500 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

Related Products

S-methyl-L-Thiocitrulline (hydrochloride)

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