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Nω-propyl-L-Arginine

Cayman Chemical Item Number 80587

(CAS 137361-05-8)

Nω-propyl-L-Arginine (CAS 137361-05-8)

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Description

Nω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). Nω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a Ki value of 57 nM.1 The Ki values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 µM, respectively. Nω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.1

1 Zhang, H.Q., Fast, W., Marletta, M.A., et al. Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J Med Chem 40 3869-3870 (1997).

Formal Name N5-​[imino(propylamino)methyl]-​L-​ornithine
CAS Number 137361-05-8
Molecular Formula C9H20N4O2
Formula Weight 216.3
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCNC(=N)​NCCC[C@H]​(N)​C(=O)​O

Background Reading

Zhang, H.Q., Fast, W., Marletta, M.A., et al. Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J Med Chem 40 3869-3870 (1997).
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