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S-(2-aminoethyl) Isothiourea (dihydrobromide)

Cayman Chemical Item Number 81005

NSC 22877; Antiradon (CAS 56-10-0)

S-(2-aminoethyl) Isothiourea (dihydrobromide) (CAS 56-10-0)

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Description

S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 µM, respectively.1

1 Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 269 26669-26676 (1994).

Synonyms
  • NSC 22877
  • Antiradon
Formal Name 2-​aminoethyl carbamimidothioate,​ dihydrobromide
CAS Number 56-10-0
Molecular Formula C3H9N3S · 2HBr
Formula Weight 281.0
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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N/C(SCCN)​=N/[H]​.[·2HBr]​

Background Reading

Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 269 26669-26676 (1994).

Jang, D., Szabó, C., and Murrell, G.A.C. S-Substituted isothioureas are potent inhibitors of nitric oxide biosynthesis in cartilage. Eur J Pharmacol 312 341-347 (1996).

Southan, G.J., Szabó, C., and Thiemermann, C. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114 510-516 (1995).

S-(2-aminoethyl) Isothiourea (dihydrobromide) is available in the following screening library:

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