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AMT (hydrochloride)

Cayman Chemical Item Number 81010

(CAS 21463-31-0)

AMT (hydrochloride) (CAS 21463-31-0)

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Description

AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.1

1 Nakane, M., Klinghofer, V., Kuk, J.E., et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol Pharmacol 47 831-834 (1995).

Formal Name 5,​6-​dihydro-​6-​methyl-​4H-​1,​3-​thiazin-​2-​amine,​ hydrochloride
CAS Number 21463-31-0
Molecular Formula C5H10N2S · HCl
Formula Weight 166.7
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC1CCN=C(N)​S1

Background Reading

Nakane, M., Klinghofer, V., Kuk, J.E., et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol Pharmacol 47 831-834 (1995).
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