See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

2,4-Diamino-6-hydroxypyrimidine

Cayman Chemical Item Number 81260

DAHP (CAS 56-06-4)

2,4-Diamino-6-hydroxypyrimidine (CAS 56-06-4)

See more

Description

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.1,2,3

1 Werner-Felmayer, G., Werner, E.R., Fuchs, D., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. J Biol Chem 268 1842-1846 (1993).

2 Sung, Y., Hotchkiss, J.H., and Dietert, R.R. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol 16 101-108 (1994).

3 Gross, S.S., and Levi, R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 267 25722-25729 (1992).

Synonyms
  • DAHP
Formal Name 2,​4-​diamino-​6(1H)-​pyrimidinone
CAS Number 56-06-4
Molecular Formula C4H6N4O
Formula Weight 126.1
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
Nc1cc(O)​nc(N)​n1

Background Reading

Sung, Y., Hotchkiss, J.H., and Dietert, R.R. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol 16 101-108 (1994).

Nakayama, D.K., Geller, D.A., Silvio, M.D., et al. Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. Am J Physiol 266 L455-L460 (1994).

Werner-Felmayer, G., Werner, E.R., Fuchs, D., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. J Biol Chem 268 1842-1846 (1993).

Doetsch, P.W., Zastawny, T.H., Martin, A.M., et al. Monomeric base damage products from adenine, guanine, and thymine induced by exposure of DNA to ultraviolet radiation. Biochemistry 34 737-742 (1995).

Gross, S.S., and Levi, R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 267 25722-25729 (1992).

Show all 5 Hide all but first 3
Size Global Purchasing
25 mg See a distributor in your region for pricing
100 mg See a distributor in your region for pricing
1 g See a distributor in your region for pricing
250 mg See a distributor in your region for pricing

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

6,7-Dimethyltetrahydropterin (hydrochloride)
7,8-dihydro-L-Biopterin
L-Sepiapterin
tetrahydro-L-Biopterin (hydrochloride)
Show all 4 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?