Cayman Chemical | 2,4-Diamino-6-hydroxypyrimidine | Description • DAHP (CAS 56-06-4)

81260 2,4-Diamino-6-hydroxypyrimidine

DAHP (CAS 56-06-4)

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2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC₅₀ for inhibition of BH₄ biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.^1,2,3

1 Werner-Felmayer, G., Werner, E.R., Fuchs, D., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. J Biol Chem 268 1842-1846 (1993).

2 Sung, Y., Hotchkiss, J.H., Dietert, R.R. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol 16 101-108 (1994).

3 Gross, S.S., Levi, R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 267 25722-25729 (1992).

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Pricing updated 2010-03-18.
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