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2,4-Diamino-6-hydroxypyrimidine

Cayman Chemical Item Number 81260

DAHP (CAS 56-06-4)

2,4-Diamino-6-hydroxypyrimidine (CAS 56-06-4)

See more	Nitric Oxide (101)

Description

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC₅₀ for inhibition of BH₄ biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.^1,2,3

1 Werner-Felmayer, G., Werner, E.R., Fuchs, D., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. J Biol Chem 268 1842-1846 (1993).

2 Sung, Y., Hotchkiss, J.H., and Dietert, R.R. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol 16 101-108 (1994).

3 Gross, S.S., and Levi, R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 267 25722-25729 (1992).

Synonyms	DAHP
Formal Name	2,4-diamino-6(1H)-pyrimidinone
CAS Number	56-06-4
Molecular Formula	C₄H₆N₄O
Formula Weight	126.1
Formulation	A crystalline solid
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Nc1cc(O)nc(N)n1

Background Reading

Sung, Y., Hotchkiss, J.H., and Dietert, R.R. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol 16 101-108 (1994).

Nakayama, D.K., Geller, D.A., Silvio, M.D., et al. Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. Am J Physiol 266 L455-L460 (1994).

Werner-Felmayer, G., Werner, E.R., Fuchs, D., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. J Biol Chem 268 1842-1846 (1993).

Doetsch, P.W., Zastawny, T.H., Martin, A.M., et al. Monomeric base damage products from adenine, guanine, and thymine induced by exposure of DNA to ultraviolet radiation. Biochemistry 34 737-742 (1995).

Gross, S.S., and Levi, R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 267 25722-25729 (1992).

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Size	Price	Quantity	Subtotal
25 mg	$7.00		$0.00
100 mg	$25.00		$0.00
1 g	$48.00		$0.00
250 mg	$56.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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