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S-ethyl Isothiourea (hydrobromide)

Cayman Chemical Item Number 81275

WR 539; SEIT (HBr); Ethiron bromide; 2-Ethyl-2-thiopseudourea hydrobromide (CAS 1071-37-0)

S-ethyl Isothiourea (hydrobromide) (CAS 1071-37-0)

See more	Nitric Oxide (101)

Description

S-ethyl Isothiourea (SEIT) is a potent inhibitor of NOS in vitro but lacks good in vivo efficacy due to poor cellular penetration. The K_i values are 19, 39, and 29 nM using purified human iNOS, eNOS, and nNOS, respectively.^1,2,3

1 Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 269 26669-26676 (1994).

2 Nakane, M., Klinghofer, V., Kuk, J.E., et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol Pharmacol 47 831-834 (1995).

3 Southan, G.J., Szabó, C., and Thiemermann, C. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114 510-516 (1995).

Synonyms	WR 539 SEIT (HBr) Ethiron bromide 2-Ethyl-2-thiopseudourea hydrobromide
Formal Name	ethyl carbamimidothioate, hydrobromide
CAS Number	1071-37-0
Molecular Formula	C₃H₈N₂S · HBr
Formula Weight	185.1
Formulation	A crystalline solid
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard N/C(SCC)=N/[H].Br

Background Reading

Garvey, E.P., Oplinger, J.A., Tanoury, G.J., et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 269 26669-26676 (1994).

Nakane, M., Klinghofer, V., Kuk, J.E., et al. Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol Pharmacol 47 831-834 (1995).

Southan, G.J., Szabó, C., and Thiemermann, C. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114 510-516 (1995).

S-ethyl Isothiourea (hydrobromide) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing
500 mg	See a distributor in your region for pricing
1 g	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

Related Products

N^G-amino-L-Arginine (hydrochloride)

S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

S-isopropyl Isothiourea (hydrobromide)

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