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S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

Cayman Chemical Item Number 81280

EPIT (CAS 163490-78-6)

S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride) (CAS 163490-78-6)

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Description

EPIT is a selective, competitive inhibitor of nNOS having a Ki of 0.32 µM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.1

1 Shearer, B.G., Lee, S., Oplinger, J.A., et al. Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem 40 1901-1905 (1997).

Synonyms
  • EPIT
Formal Name ethyl[4-​(trifluoromethyl)phenyl] carbamimidothioate,​ hydrochloride
CAS Number 163490-78-6
Molecular Formula C10H11F3N2S · HCl
Formula Weight 284.7
Formulation A crystalline solid
Purity ≥98%
λmax 245 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCS/C(N([H]​)​C1=CC=C(C(F)​(F)​F)​C=C1)​=N\[H]​.Cl

Background Reading

Shearer, B.G., Lee, S., Oplinger, J.A., et al. Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem 40 1901-1905 (1997).

S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride) is available in the following screening library:

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