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S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

Cayman Chemical Item Number 81280

EPIT (HCl) (CAS 163490-78-6)

S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride) (CAS 163490-78-6)

See more	Nitric Oxide (101)

Description

EPIT is a selective, competitive inhibitor of nNOS having a K_i of 0.32 µM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.¹

1 Shearer, B.G., Lee, S., Oplinger, J.A., et al. Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem 40 1901-1905 (1997).

Synonyms	EPIT (HCl)
Formal Name	ethyl[4-(trifluoromethyl)phenyl] carbamimidothioate, hydrochloride
CAS Number	163490-78-6
Molecular Formula	C₁₀H₁₁F₃N₂S · HCl
Formula Weight	284.7
Formulation	A crystalline solid
Purity	≥98%
λ_max	245 nm
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCS/C(N([H])C1=CC=C(C(F)(F)F)C=C1)=N\[H].Cl

Background Reading

Shearer, B.G., Lee, S., Oplinger, J.A., et al. Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem 40 1901-1905 (1997).

S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$51.00		$0.00
10 mg	$97.00		$0.00
50 mg	$408.00		$0.00
100 mg	$714.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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