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7-Nitroindazole

Cayman Chemical Item Number 81340

(CAS 2942-42-9)

7-Nitroindazole (CAS 2942-42-9)

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Description

7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS.1 The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 µM, respectively.2

1 Moore, P.K., Babbedge, R.C., Wallace, P., et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol 108 296-297 (1993).

2 Bland-Ward, P.A., Pitcher, A., Wallace, P., et al. Isoform selectivity of indazole-based nitric oxide synthase inhibitors. Br J Pharmacol 112 351P (1994).

Formal Name 7-​nitro-​1H-​indazole
CAS Number 2942-42-9
Molecular Formula C7H5N3O2
Formula Weight 163.1
Formulation A crystalline solid
Purity >98%
λmax 228, 300, 357 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[N]​(=O)​c1cccc2cn[nH]​c12

Background Reading

Babbedge, R.C., Bland-Ward, P.A., Hart, S.L., et al. Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br J Pharmacol 110 225-228 (1993).

Moore, P.K., Babbedge, R.C., Wallace, P., et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol 108 296-297 (1993).

Bland-Ward, P.A., Pitcher, A., Wallace, P., et al. Isoform selectivity of indazole-based nitric oxide synthase inhibitors. Br J Pharmacol 112 351P (1994).
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