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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

ODQ

Cayman Chemical Item Number 81410

(CAS 41443-28-1)

ODQ (CAS 41443-28-1)

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Description

ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase.1,2 The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.2

1 Garthwaite, J., Southam, E., Boulton, C.L., et al. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol 48 184-188 (1995).

2 Schrammel, A., Behrends, S., Schmidt, K., et al. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol 50 1-5 (1996).

Formal Name 1H-​[1,​2,​4]oxadiazolo[4,​3-​a]quinoxalin-​1-​one
CAS Number 41443-28-1
Molecular Formula C9H5N3O2
Formula Weight 187.2
Formulation A crystalline solid
Purity >98%
λmax 232, 295 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1ON=C2C=NC3=CC=CC=C3N21

Background Reading

Schrammel, A., Behrends, S., Schmidt, K., et al. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol 50 1-5 (1996).

Garthwaite, J., Southam, E., Boulton, C.L., et al. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol 48 184-188 (1995).

ODQ is available in the following screening library:

Size Price Quantity Subtotal
5 mg $23.00 $0.00
10 mg $44.00 $0.00
50 mg $184.00 $0.00
100 mg $322.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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