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1400W (hydrochloride)

Cayman Chemical Item Number 81520

(CAS 214358-33-5)

1400W (hydrochloride) (CAS 214358-33-5)

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Description

1400W is a potent, selective inhibitor of iNOS.1 Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.1 In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.1 In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.2

1 Garvey, E.P., Oplinger, J.A., Furfine, E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272 4959-4963 (1997).

2 Thomsen, L.L., Scott, J.M.J., Topley, P., et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor. Cancer Res 57 3300-3304 (1997).

Formal Name N-​[[3-​(aminomethyl)phenyl]methyl]-​ethanimidamide,​ dihydrochloride
CAS Number 214358-33-5
Molecular Formula C10H15N3 · 2HCl
Formula Weight 250.2
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NCc1cccc(CNC(=N)​C)​c1

Background Reading

Garvey, E.P., Oplinger, J.A., Furfine, E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272 4959-4963 (1997).

Thomsen, L.L., Scott, J.M.J., Topley, P., et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor. Cancer Res 57 3300-3304 (1997).
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