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1400W (hydrochloride)

Cayman Chemical Item Number 81520

(CAS 214358-33-5)

1400W (hydrochloride) (CAS 214358-33-5)

See more	Inhibitors (493) Nitric Oxide (101)

Description

1400W is a potent, selective inhibitor of iNOS.¹ Using purified human iNOS, nNOS, and eNOS, 1400W exhibits K_i values of 7 nM, 2 µM, and 50 µM, respectively.¹ In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.¹ In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.²

1 Garvey, E.P., Oplinger, J.A., Furfine, E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272 4959-4963 (1997).

2 Thomsen, L.L., Scott, J.M.J., Topley, P., et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor. Cancer Res 57 3300-3304 (1997).

Formal Name	N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride
CAS Number	214358-33-5
Molecular Formula	C₁₀H₁₅N₃ · 2HCl
Formula Weight	250.2
Formulation	A crystalline solid
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard NCc1cccc(CNC(=N)C)c1

Background Reading

Garvey, E.P., Oplinger, J.A., Furfine, E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272 4959-4963 (1997).

Thomsen, L.L., Scott, J.M.J., Topley, P., et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor. Cancer Res 57 3300-3304 (1997).

Size	Price	Quantity	Subtotal
5 mg	$42.00		$0.00
10 mg	$80.00		$0.00
50 mg	$336.00		$0.00
100 mg	$588.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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TRIM

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