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Aminoguanidine (hydrochloride)

Cayman Chemical Item Number 81530

Pimagedine; GER 11; Aminoguanidinium chloride (CAS 1937-19-5)

Aminoguanidine (hydrochloride) (CAS 1937-19-5)

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Description

Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.1,2 The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.2 Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.3

1 Joly, G.A., Ayres, M., Chelly, F., et al. Effects of NG-methyl-L-arginine, NG-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 199 147-154 (1994).

2 Misko, T.P., Moore, W.M., Kasten, T.P., et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 233 119-125 (1993).

3 Ruetten, H., and Thiemermann, C. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem Biophys Res Commun 225 525-530 (1996).

Synonyms
  • Pimagedine
  • GER 11
  • Aminoguanidinium chloride
Formal Name hydrazinecarboximidamide,​ monohydrochloride
CAS Number 1937-19-5
Molecular Formula CH6N4 · HCl
Formula Weight 110.5
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NNC(=N)​N

Background Reading

Joly, G.A., Ayres, M., Chelly, F., et al. Effects of NG-methyl-L-arginine, NG-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 199 147-154 (1994).

Ruetten, H., and Thiemermann, C. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem Biophys Res Commun 225 525-530 (1996).

Misko, T.P., Moore, W.M., Kasten, T.P., et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 233 119-125 (1993).
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