See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Aminoguanidine (hydrochloride)

Cayman Chemical Item Number 81530

Pimagedine; GER 11; Aminoguanidinium chloride (CAS 1937-19-5)

Aminoguanidine (hydrochloride) (CAS 1937-19-5)

See more

Description

Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.1,2 The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.2 Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.3

1 Joly, G.A., Ayres, M., Chelly, F., et al. Effects of NG-methyl-L-arginine, NG-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 199 147-154 (1994).

2 Misko, T.P., Moore, W.M., Kasten, T.P., et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 233 119-125 (1993).

3 Ruetten, H., and Thiemermann, C. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem Biophys Res Commun 225 525-530 (1996).

Synonyms
  • Pimagedine
  • GER 11
  • Aminoguanidinium chloride
Formal Name hydrazinecarboximidamide,​ monohydrochloride
CAS Number 1937-19-5
Molecular Formula CH6N4 · HCl
Formula Weight 110.5
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
NNC(=N)​N

Background Reading

Joly, G.A., Ayres, M., Chelly, F., et al. Effects of NG-methyl-L-arginine, NG-nitro-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 199 147-154 (1994).

Ruetten, H., and Thiemermann, C. Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochem Biophys Res Commun 225 525-530 (1996).

Misko, T.P., Moore, W.M., Kasten, T.P., et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 233 119-125 (1993).
Size Price Quantity Subtotal
10 g $10.00 $0.00
25 g $24.00 $0.00
50 g $45.00 $0.00
100 g $80.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

1,3-PBIT (dihydrobromide)
1400W (hydrochloride)
AMT (hydrochloride)
Diphenyleneiodonium Chloride
L-NIL (hydrochloride)
L-NMMA (acetate)
L-NMMA (citrate)
L-NNA
Show all 8 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?