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YC-1

Cayman Chemical Item Number 81560

(CAS 170632-47-0)

YC-1 (CAS 170632-47-0)

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Description

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM, respectively.1,2 In the absence of NO or carbon monoxide (CO), 200 µM YC-1 increases the activity of purified soluble guanylyl cyclase 12-fold, with an ED50 value of 20 µM.3 At a concentration of 200 µM, YC-1 potentiates the maximal activity of soluble guanylyl cyclase in the presence of NO or CO by 40% and >3,000%, respectively.

1 Wu, C., Ko, F., Kuo, S., et al. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br J Pharmacol 116 1973-1978 (1995).

2 Ko, F., Wu, C., Kuo, S., et al. YC-1, a novel activator of platelet guanylate cyclase. Blood 84 4226-4233 (1994).

3 Friebe, A., Schultz, G., and Koesling, D. Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO J 15 6863-6868 (1996).

Formal Name 5-​[1-​(phenylmethyl)-​1H-​indazol-​3-​yl]-​2-​furanmethanol
CAS Number 170632-47-0
Molecular Formula C19H16N2O2
Formula Weight 304.3
Formulation A crystalline solid
Purity >99%
λmax 225, 253, 278, 287, 326 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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OCC1=CC=C(C2=NN(CC3=CC=CC=C3)​C4=C2C=CC=C4)​O1

Background Reading

Wu, C., Ko, F., Kuo, S., et al. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br J Pharmacol 116 1973-1978 (1995).

Ko, F., Wu, C., Kuo, S., et al. YC-1, a novel activator of platelet guanylate cyclase. Blood 84 4226-4233 (1994).

Friebe, A., Schultz, G., and Koesling, D. Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO J 15 6863-6868 (1996).

YC-1 is available in the following screening library:

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5 mg See a distributor in your region for pricing
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50 mg See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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