Peroxynitrite is formed in vivo by the reaction of NO with superoxide.1,2,3 It is a powerful oxidizing agent that can initiate lipid peroxidation, oxidize sulfhydryls, and nitrates the aromatic residues of proteins.
1
Pryor, W.A., and Squadrito, G.L. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol268L699-L722(1995).
2
Beckman, J.S., and Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am J Physiol271C1424-C1437(1996).
3
Koppenol, W.H., Moreno, J.J., Pryor, W.A., et al. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem Res Toxicol5834-842(1992).
Synonyms
Sodium Peroxynitrite
Formal Name
peroxynitrous acid, sodium salt
CAS Number
14042-01-4
Molecular Formula
ONO2 · Na
Formula Weight
85.0
Formulation
A solution in 0.3 M sodium hydroxide
Purity
>90% (balance is NO2/NO3)
λmax
302 nm
ε
1
Stability
6 months
Storage
-80°C
Shipping
Dry ice
in continental US; may vary elsewhere
SMILES
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CON=O
Background Reading
Pryor, W.A., and Squadrito, G.L. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol268L699-L722(1995).
Koppenol, W.H., Moreno, J.J., Pryor, W.A., et al. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem Res Toxicol5834-842(1992).
Beckman, J.S., and Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am J Physiol271C1424-C1437(1996).
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