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NS-2028

Cayman Chemical Item Number 81600

(CAS 204326-43-2)

NS-2028 (CAS 204326-43-2)

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Description

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively.1 S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay.1 NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

1 Olesen, S., Drejer, J., Axelsson, O., et al. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol 123 299-309 (1998).

Formal Name 8-​bromo-​4H-​2,​5-​dioxa-​3,​9b-​diaza-​cyclopenta[a]naphthalen-​1-​one
CAS Number 204326-43-2
Molecular Formula C9H5BrN2O3
Formula Weight 269.1
Formulation A crystalline solid
Purity >99%
λmax 218, 287 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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Brc1ccc2OCc3noc(=O)​n3c2c1

Background Reading

Olesen, S., Drejer, J., Axelsson, O., et al. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol 123 299-309 (1998).

NS-2028 is available in the following screening library:

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Related Products

ODQ
YC-1

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