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NS-2028

Cayman Chemical Item Number 81600

(CAS 204326-43-2)

NS-2028 (CAS 204326-43-2)

See more	Inhibitors (493)

Description

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC₅₀ values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively.¹ S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC₅₀ value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC₅₀ value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay.¹ NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

1 Olesen, S., Drejer, J., Axelsson, O., et al. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol 123 299-309 (1998).

Formal Name	8-bromo-4H-2,5-dioxa-3,9b-diaza-cyclopenta[a]naphthalen-1-one
CAS Number	204326-43-2
Molecular Formula	C₉H₅BrN₂O₃
Formula Weight	269.1
Formulation	A crystalline solid
Purity	>99%
λ_max	218, 287 nm
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Brc1ccc2OCc3noc(=O)n3c2c1

Background Reading

Olesen, S., Drejer, J., Axelsson, O., et al. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol 123 299-309 (1998).

NS-2028 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$37.00		$0.00
5 mg	$167.00		$0.00
10 mg	$296.00		$0.00
25 mg	$648.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

ODQ

YC-1

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