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DEA NONOate

Cayman Chemical Item Number 82100

DEA/NO; Diethylamine NONOate (CAS 372965-00-9)

DEA NONOate (CAS 372965-00-9)

See more	NO Donors (26) Nitric Oxide (101)

Description

DEA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2 minutes and 16 minutes at 37°C and 22-25°C, pH 7.4, respectively, to liberate 1.5 moles of NO per mole of parent compound.^1,2

1 Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

2 Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

Synonyms	DEA/NO Diethylamine NONOate
Formal Name	Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate
CAS Number	372965-00-9
Molecular Formula	C₄H₁₁N₃O₂ · C₄H₁₁N
Formula Weight	206.3
Formulation	A crystalline solid
Purity	≥98%
λ_max	250 nm
ε	9
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCN(N([O-])N=O)CC.CC[NH2+]CC

Background Reading

Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

Laval, F., and Wink, D.A. Inhibition by nitric oxide of the repair protein, O⁶-methylguanine-DNA-methyltransferase. Carcinogenesis 5 443-447 (1994).

Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

Maragos, C.M., Wang, J.M., Hrabie, J.A., et al. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. Cancer Res 53 564-568 (1993).

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Size	Global Purchasing
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500 mg	See a distributor in your region for pricing

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