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PAPA NONOate

Cayman Chemical Item Number 82140

Propylamine Propylamine NONOate (CAS 146672-58-4)

PAPA NONOate (CAS 146672-58-4)

See more	NO Donors (26) Nitric Oxide (101)

Description

PAPA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 15 minutes and 77 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.^1,2

1 Hrabie, J.A., Klose, J.R., Wink, D.A., et al. New nitric oxide-releasing zwitterions derived from polyamines. J Org Chem 58 1472-1476 (1993).

2 Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

Synonyms	Propylamine Propylamine NONOate
Formal Name	(Z)-1-[N-(3-aminopropyl)-N-(n-propyl)amino]diazen-1-ium-1,2-diolate
CAS Number	146672-58-4
Molecular Formula	C₆H₁₆N₄O₂
Formula Weight	176.2
Formulation	A crystalline solid
Purity	>98%
λ_max	250 nm
ε	8
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCN(CCCN)N(O)N=O

Background Reading

Maragos, C.M., Wang, J.M., Hrabie, J.A., et al. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. Cancer Res 53 564-568 (1993).

Hrabie, J.A., Klose, J.R., Wink, D.A., et al. New nitric oxide-releasing zwitterions derived from polyamines. J Org Chem 58 1472-1476 (1993).

PAPA NONOate is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
25 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing
500 mg	See a distributor in your region for pricing

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