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Spermine NONOate

Cayman Chemical Item Number 82150

(CAS 136587-13-8)

Spermine NONOate (CAS 136587-13-8)

See more	NO Donors (26) Nitric Oxide (101)

Description

Spermine NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.^1,2

1 Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

2 Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

Formal Name	(Z)-1-[N-[3-aminopropyl]-N-[4-(3-aminopropylammonio)butyl]-amino]diazen-1-ium-1,2-diolate
CAS Number	136587-13-8
Molecular Formula	C₁₀H₂₆N₆O₂
Formula Weight	262.4
Formulation	A crystalline solid
Purity	>98%
λ_max	252 nm
ε	8
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard NCCCNCCCCN(CCCN)N(O)N=O

Background Reading

Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

Maragos, C.M., Wang, J.M., Hrabie, J.A., et al. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. Cancer Res 53 564-568 (1993).

Wink, D.A., Hanbauer, I., Krishna, M.C., et al. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc Natl Acad Sci USA 90 9813-9817 (1993).

Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

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Spermine NONOate is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
10 mg	See a distributor in your region for pricing
25 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing

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