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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

SIN-1 Chloride

Cayman Chemical Item Number 82220

Linsidomine; 3-Morpholino-sydnonimine (CAS 16142-27-1)

SIN-1 Chloride (CAS 16142-27-1)

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Description

As the active metabolite of molsidomine, SIN-1 chloride is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.1,2,3

1 Rosenkranz, B., Winkelmann, B.R., and Parnham, M.J. Clinical pharmacokinetics of molsidomine. Clin Pharmacokinet 30 372-384 (1996).

2 Lomonosova, E.E., Kirsch, M., Rauen, U., et al. The critical role of hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide. Free Radic Biol Med 24 522-528 (1998).

3 Nishikawa, M., Kanamori, M., and Hidaka, H. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther 220 183-190 (1982).

Synonyms
  • Linsidomine
  • 3-Morpholino-sydnonimine
Formal Name 5-​amino-​3-​(4-​morpholinyl)-​1,​2,​3-​oxadiazolium chloride
CAS Number 16142-27-1
Molecular Formula C6H11N4O2 · Cl
Formula Weight 206.6
Formulation A crystalline solid
Purity >99%
λmax 253, 296 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC1=C[N+]​(N2CCOCC2)​=NO1.[Cl-]​

Background Reading

Henry, P.J., Horowitz, J.D., and Louis, W.J. Nitroglycerin-induced tolerance affects multiple sites in the organic nitrate bioconversion cascade. J Pharmacol Exp Ther 248 762-768 (1989).

Rosenkranz, B., Winkelmann, B.R., and Parnham, M.J. Clinical pharmacokinetics of molsidomine. Clin Pharmacokinet 30 372-384 (1996).

Sanduja, S.K., Tsai, A., Matijevic-Aleksic, N., et al. Kinetics of prostacyclin synthesis in PGHS-1-overexpressed endothelial cells. Am J Physiol 267 C1459-C1466 (1994).

Lipton, S.A., Choi, Y., Pan, Z., et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364 626-632 (1993).

Nishikawa, M., Kanamori, M., and Hidaka, H. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther 220 183-190 (1982).

Lomonosova, E.E., Kirsch, M., Rauen, U., et al. The critical role of hepes in SIN-1 cytotoxicity, peroxynitrite versus hydrogen peroxide. Free Radic Biol Med 24 522-528 (1998).

Show all 6 Hide all but first 3
Size Price Quantity Subtotal
5 mg $14.00 $0.00
10 mg $27.00 $0.00
50 mg $112.00 $0.00
100 mg $196.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Molsidomine
Peroxynitrite

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