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Angeli’s Salt

Cayman Chemical Item Number 82230

Sodium α-oxyhyponitrite (CAS 13826-64-7)

Angeli's Salt (CAS 13826-64-7)

See more	NO Donors (26) Nitric Oxide (101)

Description

Angeli’s salt is regarded as a classical nitroxyl (NO-) donor, but under certain conditions evolution of NO is also observed.¹ It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4) to liberate 0.54 moles of NO per mole of parent compound.^1,2

1 Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

2 Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

Synonyms	Sodium α-oxyhyponitrite
Formal Name	disodium diazen-1-ium-1,2,2-triolate
CAS Number	13826-64-7
Molecular Formula	Na₂(ONNO₂)
Formula Weight	122.0
Formulation	A crystalline solid
Purity	>99%
Stability	6 months
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ON=N(=O)O

Background Reading

Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

Fukuto, J.M., Hobbs, A.J., and Ignarro, L.J. Conversion of nitroxyl (HNO) to nitric oxide in biological systems: The role of physiological oxidants and relevance to the biological activity of HNO. Biochem Biophys Res Commun 196 707-713 (1993).

Size	Global Purchasing
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10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing

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