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S-Nitroso-L-glutathione

Cayman Chemical Item Number 82240

GSNO (CAS 57564-91-7)

S-Nitroso-L-glutathione (CAS 57564-91-7)

See more	NO Donors (26) Nitric Oxide (101)

Description

S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.^1,2,3,4

1 Radomski, M.W., Rees, D.D., Dutra, A., et al. S-Nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol 107 745-749 (1992).

2 Butler, A.R., and Rhodes, P. Chemistry, analysis, and biological roles of S-nitrosothiols. Anal Biochem 249 1-9 (1997).

3 Gasco, A., Fruttero, R., and Sorba, G. NO-donors: An emerging class of compounds in medicinal chemistry. Farmaco 51 617-635 (1996).

4 Cook, J.A., Kim, S.Y., Teague, D., et al. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal Biochem 238 150-158 (1996).

Synonyms	GSNO
Formal Name	N-(N-L-γ-glutamyl-S-nitroso-L-cysteinyl)-glycine
CAS Number	57564-91-7
Molecular Formula	C₁₀H₁₆N₄O₇S
Formula Weight	336.3
Formulation	A crystalline solid
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard N[C@@H](CCC(N([H])[C@H](CSN=O)C(N([H])CC(O)=O)=O)=O)C(O)=O

Background Reading

Clark, A.G., and Debnam, P. Inhibition of glutathione S-transferases from rat liver by S-nitroso-L-glutathione. Biochem Pharmacol 37 3199-3201 (1988).

Gibson, A., Babbedge, R., Brave, S.R., et al. An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus. Br J Pharmacol 107 715-721 (1992).

Radomski, M.W., Rees, D.D., Dutra, A., et al. S-Nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol 107 745-749 (1992).

Gasco, A., Fruttero, R., and Sorba, G. NO-donors: An emerging class of compounds in medicinal chemistry. Farmaco 51 617-635 (1996).

Butler, A.R., and Rhodes, P. Chemistry, analysis, and biological roles of S-nitrosothiols. Anal Biochem 249 1-9 (1997).

Cook, J.A., Kim, S.Y., Teague, D., et al. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal Biochem 238 150-158 (1996).

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S-Nitroso-L-glutathione is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing
100 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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