Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

S-Nitroso-L-glutathione

Cayman Chemical Item Number 82240

GSNO (CAS 57564-91-7)

S-Nitroso-L-glutathione (CAS 57564-91-7)

See more	NO Donors (26) Nitric Oxide (101)

Description

S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.^1,2,3,4

1 Radomski, M.W., Rees, D.D., Dutra, A., et al. S-Nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol 107 745-749 (1992).

2 Butler, A.R., and Rhodes, P. Chemistry, analysis, and biological roles of S-nitrosothiols. Anal Biochem 249 1-9 (1997).

3 Gasco, A., Fruttero, R., and Sorba, G. NO-donors: An emerging class of compounds in medicinal chemistry. Farmaco 51 617-635 (1996).

4 Cook, J.A., Kim, S.Y., Teague, D., et al. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal Biochem 238 150-158 (1996).

Synonyms	GSNO
Formal Name	N-(N-L-γ-glutamyl-S-nitroso-L-cysteinyl)-glycine
CAS Number	57564-91-7
Molecular Formula	C₁₀H₁₆N₄O₇S
Formula Weight	336.3
Formulation	A crystalline solid
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard N[C@@H](CCC(N([H])[C@H](CSN=O)C(N([H])CC(O)=O)=O)=O)C(O)=O

Background Reading

Clark, A.G., and Debnam, P. Inhibition of glutathione S-transferases from rat liver by S-nitroso-L-glutathione. Biochem Pharmacol 37 3199-3201 (1988).

Gibson, A., Babbedge, R., Brave, S.R., et al. An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus. Br J Pharmacol 107 715-721 (1992).

Radomski, M.W., Rees, D.D., Dutra, A., et al. S-Nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol 107 745-749 (1992).

Gasco, A., Fruttero, R., and Sorba, G. NO-donors: An emerging class of compounds in medicinal chemistry. Farmaco 51 617-635 (1996).

Butler, A.R., and Rhodes, P. Chemistry, analysis, and biological roles of S-nitrosothiols. Anal Biochem 249 1-9 (1997).

Cook, J.A., Kim, S.Y., Teague, D., et al. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal Biochem 238 150-158 (1996).

Show all 6 Hide all but first 3

S-Nitroso-L-glutathione is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$18.00		$0.00
10 mg	$34.00		$0.00
50 mg	$144.00		$0.00
100 mg	$252.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Glutathione Cell-Based Detection Kit (Blue Fluorescence)

L-Glutathione, reduced

MAHMA NONOate

Show all 8 Hide all but first 3

Downloads

	Download Product Insert 129 Kb PDF
	Download Material Safety Data Sheet (MSDS) 100 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640