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FK-409

Cayman Chemical Item Number 82290

NOR-3 (CAS 138472-01-2)

FK-409 (CAS 138472-01-2)

See more	NO Donors (26) Nitric Oxide (101)

Description

FK-409 is a NO donor. It liberates NO in a time-dependent manner with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C.¹ The IC₅₀ for the inhibition of platelet aggregation is 4.9 µM.²

1 Kita, Y., Hirasawa, Y., Maeda, K., et al. Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. Eur J Pharmacol 257 123-130 (1994).

2 Fukuyama, S., Hirasawa, Y., Kato, Y., et al. Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. J Pharmacol Exp Ther 282 236-242 (1997).

Synonyms	NOR-3
Formal Name	4-ethyl-2E-(hydroxyimino)-5-nitro-3E-hexenamide
CAS Number	138472-01-2
Molecular Formula	C₈H₁₃N₃O₄
Formula Weight	215.2
Formulation	A crystalline solid
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC/C(=C\C(=N\O)/C(=O)N)/C(C)[N+](=O)[O-]

Background Reading

Kita, Y., Hirasawa, Y., Maeda, K., et al. Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. Eur J Pharmacol 257 123-130 (1994).

Fukuyama, S., Hirasawa, Y., Kato, Y., et al. Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. J Pharmacol Exp Ther 282 236-242 (1997).

FK-409 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
50 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

Related Products

S-Nitroso-L-glutathione

Spermine NONOate

V-PYRRO/NO

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