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SE 175

Cayman Chemical Item Number 82340

(CAS 258278-64-7)

SE 175 (CAS 258278-64-7)

See more	NO Donors (26) Nitric Oxide (101)

Description

SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC₅₀ of 20 µM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.¹

1 Endres, S., Hacker, A., Noack, E., et al. NO-donors, Part 3: Nitrooxyacylated thiosalicylates and salicylates-synthesis and biological activities. Eur J Med Chem 34 895-901 (1999).

Formal Name	2-[[4-[(nitrooxy)methyl]benzoyl]thio]-benzoic acid, methyl ester
CAS Number	258278-64-7
Molecular Formula	C₁₆H₁₃NO₆S
Formula Weight	347.3
Formulation	A crystalline solid
Purity	>97%
λ_max	205, 243, 278 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COC(=O)c1ccccc1SC(=O)c1ccc(CO[N](=O)O)cc1

Background Reading

Endres, S., Hacker, A., Noack, E., et al. NO-donors, Part 3: Nitrooxyacylated thiosalicylates and salicylates-synthesis and biological activities. Eur J Med Chem 34 895-901 (1999).

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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