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Sulpho NONOate

Cayman Chemical Item Number 83300

(CAS 61142-90-3)

Sulpho NONOate (CAS 61142-90-3)

See more	NO Donors (26) Nitric Oxide (101)

Description

Sulpho NONOate produces nitrous oxide but no NO at physiological pH. Therefore, this compound may be used as a negative control in experiments using other NO donors of the NONOate class.^1,2

1 Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

2 Keefer, L.K., Nims, R.W., Davies, K.M., et al. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms. Methods Enzymol 268 281-293 (1996).

Formal Name	disodium (E)-1-sulfonatodiazen-1-ium-1,2-diolate
CAS Number	61142-90-3
Molecular Formula	N₂O₅S · 2Na
Formula Weight	186.1
Formulation	A crystalline solid
Purity	>90%
λ_max	259 nm
ε	7
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=NN(O)S(=O)(=O)O

Background Reading

Maragos, C.M., Morley, D., Wink, D.A., et al. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 3242-3247 (1991).

Maragos, C.M., Wang, J.M., Hrabie, J.A., et al. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. Cancer Res 53 564-568 (1993).

Switkes, E.G., Dasch, G.A., and Ackermann, M.N. Kinetics of boric acid catalyzed decomposition of the N-nitrosohydroxylamine-N-sulfonate ion. Inorg Chem 12 1120-1123 (1973).

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