Cayman Chemical | 8-hydroxy Guanine | Description • 8-Oxoguanine

89290 8-hydroxy Guanine

8-Oxoguanine

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• See more Oxidative Injury

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

8-hydroxy Guanine is produced by oxidative damage of DNA or RNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.^1,2,3,4,5

1 Beckman, K.B., Ames, B.N. Oxidative decay of DNA. J Biol Chem 272 19633-19636 (1997).

2 Park, E., Shigenaga, M.K., Degan, P., et al. Assay of excised oxidative DNA lesions: Isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proc Natl Acad Sci USA 89 3375-3379 (1992).

3 Jaruga, P., Zastawny, T.H., Skokowski, J., et al. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Lett 341 59-64 (1994).

4 Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett 374 233-236 (1995).

5 Epe, B., Ballmaier, D., Roussyn, I., et al. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res 24 4105-4110 (1996).

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Purchase 89290 8-hydroxy Guanine

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

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Warning This product is not for human or veterinary use.

Pricing updated 2010-03-20.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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