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8-hydroxy Guanosine

Cayman Chemical Item Number 89300

8-hydroxy Guanosine

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Description

8-hydroxy Guanosine is produced by oxidative damage of RNA.1,2 It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-hydroxy guanosine (5-8 mM) is added to Friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.3,4

1 Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4 2587-2597 (1990).

2 Taddei, F., Hayakawa, H., Bouton, M., et al. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science 278 128-130 (1997).

3 Mo, Y., Maki, H., and Sekiguchi, M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of necleotide pool. Proc Natl Acad Sci USA 89 11021-11025 (1992).

4 Lin, T., Cheng, J., Ishiguro, K., et al. 8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of friend erythroleukemia cells. J Med Chem 28 1194-1198 (1985).

Formal Name 8-​hydroxy-​guanosine
Molecular Formula C10H13N5O6
Formula Weight 299.2
Formulation A crystalline solid
Purity ≥98%
λmax 250, 296 nm
Stability 1 year
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC(N1[H]​)​=NC(N([C@H]​2[C@H]​(O)​[C@H]​(O)​[C@@H]​(CO)​O2)​C(O)​=N3)​=C3C1=O

Background Reading

Lin, T., Cheng, J., Ishiguro, K., et al. 8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of friend erythroleukemia cells. J Med Chem 28 1194-1198 (1985).

Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4 2587-2597 (1990).

Mo, Y., Maki, H., and Sekiguchi, M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of necleotide pool. Proc Natl Acad Sci USA 89 11021-11025 (1992).

Taddei, F., Hayakawa, H., Bouton, M., et al. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science 278 128-130 (1997).

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8-hydroxy Guanosine is available in the following screening library:

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Warning This product is not for human or veterinary use.

Related Products

8-hydroxy-2-deoxy Guanosine Exclusive
8-hydroxy Guanine

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