Cayman Chemical | 8-hydroxy Guanosine

89300 8-hydroxy Guanosine

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• See more Inhibitors; Cancer; Oxidative Injury

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8-hydroxy Guanosine is produced by oxidative damage of RNA.^1,2 It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-hydroxy guanosine (5-8 mM) is added to Friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.^3,4

1 Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4 2587-2597 (1990).

2 Taddei, F., Hayakawa, H., Bouton, M., et al. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science 278 128-130 (1997).

3 Mo, Y., Maki, H., Sekiguchi, M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of necleotide pool. Proc Natl Acad Sci USA 89 11021-11025 (1992).

4 Lin, T., Cheng, J., Ishiguro, K., et al. 8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of friend erythroleukemia cells. J Med Chem 28 1194-1198 (1985).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.