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8-hydroxy-2-deoxy Guanosine Exclusive

Cayman Chemical Item Number 89320

8-OH-dG

8-hydroxy-2-deoxy Guanosine

See more	Reactive Probes (27) Oxidative Injury (291)

Description

8-hydroxy-2-deoxy Guanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.^1,2,3,4

1 Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4 2587-2597 (1990).

2 Beckman, K.B., and Ames, B.N. Oxidative decay of DNA. J Biol Chem 272 19633-19636 (1997).

3 Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett 374 233-236 (1995).

4 Epe, B., Ballmaier, D., Roussyn, I., et al. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res 24 4105-4110 (1996).

Synonyms	8-OH-dG
Formal Name	2'-deoxy-8-hydroxy-guanosine
Molecular Formula	C₁₀H₁₃N₅O₅
Formula Weight	283.2
Formulation	A crystalline solid
Purity	≥98%
λ_max	206, 249, 296 nm
Stability	1 year
Storage	Room temperature
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard NC(N1[H])=NC(N([C@H]2C[C@H](O)[C@@H](CO)O2)C(O)=N3)=C3C1=O

Background Reading

Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4 2587-2597 (1990).

Beckman, K.B., and Ames, B.N. Oxidative decay of DNA. J Biol Chem 272 19633-19636 (1997).

Epe, B., Ballmaier, D., Roussyn, I., et al. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res 24 4105-4110 (1996).

Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett 374 233-236 (1995).

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8-hydroxy-2-deoxy Guanosine is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
25 mg	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

Related Products

8-hydroxy Guanine

8-hydroxy Guanosine

Epigallocatechin Gallate

Hydroxymethyl Uracil

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