Cayman Chemical | 8-hydroxy-2-deoxy Guanosine

89320 8-hydroxy-2-deoxy Guanosine

8-OH-dG

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8-hydroxy-2-deoxy Guanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.^1,2,3,4

1 Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4 2587-2597 (1990).

2 Beckman, K.B., Ames, B.N. Oxidative decay of DNA. J Biol Chem 272 19633-19636 (1997).

3 Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett 374 233-236 (1995).

4 Epe, B., Ballmaier, D., Roussyn, I., et al. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res 24 4105-4110 (1996).

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Purchase 89320 8-hydroxy-2-deoxy Guanosine

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Pricing updated 2010-03-18.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.