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Hydroxymethyl Uracil

Cayman Chemical Item Number 89360

(CAS 4433-40-3)

Hydroxymethyl Uracil (CAS 4433-40-3)

See more	Oxidative Injury (291)

Description

Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.^1,2,3

1 Zastawny, T.H., Altman, S.A., Randers-Eichhorn, L., et al. DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions. Free Radic Biol Med 18 1013-1022 (1995).

2 Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett 374 233-236 (1995).

3 Jaruga, P., Zastawny, T.H., Skokowski, J., et al. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Lett 341 59-64 (1994).

Formal Name	5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione
CAS Number	4433-40-3
Molecular Formula	C₅H₆N₂O₃
Formula Weight	142.1
Formulation	A crystalline solid
Purity	≥98%
λ_max	263 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(N1[H])C(CO)=CN([H])C1=O

Background Reading

Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett 374 233-236 (1995).

Jaruga, P., Zastawny, T.H., Skokowski, J., et al. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Lett 341 59-64 (1994).

Zastawny, T.H., Altman, S.A., Randers-Eichhorn, L., et al. DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions. Free Radic Biol Med 18 1013-1022 (1995).

Hydroxymethyl Uracil is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Global Purchasing
250 mg	See a distributor in your region for pricing
1 g	See a distributor in your region for pricing
5 g	See a distributor in your region for pricing
10 g	See a distributor in your region for pricing

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Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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