Cayman Chemical | γ-CEHC | Description • γ-Tocopherol Metabolite; GTM; 2,7,8-trimethyl-2-(β-Carboxy-Ethyl)-6-Hydroxychroman (CAS 178167-75-4)

89630 γ-CEHC

γ-Tocopherol Metabolite; GTM; 2,7,8-trimethyl-2-(β-Carboxy-Ethyl)-6-Hydroxychroman (CAS 178167-75-4)

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• See more Free Radical Generators; Endocrinology; Oxidative Injury

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The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements. γ-CEHC is a β-oxidized metabolite of dietary γ-tocopherol that functions as a natriuretic hormone.¹ It was initially purified and characterized from the urine of uremic patients, but it has since been found in urine from both control patients and those with congestive heart failure.² γ-CEHC is also anti-inflammatory, reducing 8-isoprostane and inflammatory eicosanoid synthesis in rat models.³

1 Christen, S., Woodall, A.A., Shigenaga, M.K., et al. γ-Tocopherol traps mutagenic electrophiles such as NOx and complements a-tocopherol: Physiological implications. Proc Natl Acad Sci USA 94 3217-3222 (1997).

2 Wechter, W.J., Kantoci, D., Murray, E.D., et al. A new endogenous natriuretic factor: LLU-α Proc Natl Acad Sci USA 93, 6002-6007 (1996).

3 Jiang, Q., Elson-Schwab, I., Courtemanche, C., et al. γ-Tocopherol and its major metabolite, in contrast to a-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc Natl Acad Sci USA 97 11494-11499 (2000).

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Pricing updated 2010-03-20.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.