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Trichostatin A

Cayman Chemical Item Number 89730

TSA (CAS 58880-19-6)

Trichostatin A (CAS 58880-19-6)

See more	Histone Deacetylase (14) Nuclear Receptors (94) Cancer (666) Epigenetics (198)

Description

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G₁ and inhibits the activity of the HDAC1 with an IC₅₀ value of 70 nM.¹ Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.²

1 Hoshikawa, Y., Kwon, H.J., Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp Cell Res 214 189-197 (1994).

2 Taunton, J., Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

Synonyms	TSA
Formal Name	7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
CAS Number	58880-19-6
Molecular Formula	C₁₇H₂₂N₂O₃
Formula Weight	302.4
Formulation	A crystalline solid
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ONC(=O)\C=C/C(=C\[C@@H](C)C(=O)c1ccc(cc1)N(C)C)\C

Background Reading

Taunton, J., Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

Hoshikawa, Y., Kwon, H.J., Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp Cell Res 214 189-197 (1994).

Trichostatin A is available in the following screening libraries:

Size	Global Purchasing
500 µg	See a distributor in your region for pricing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing

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