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CAY10398 Exclusive

Cayman Chemical Item Number 89740

CAY10398

See more	Histone Deacetylase (14) Cancer (666)

Description

CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC₅₀ value of 10 µM.¹ Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.² However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC.

1 Jung, M., Hoffmann, K., Brosch, G., et al. Analogues of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Bioorg Med Chem Lett 7 1655-1658 (1997).

2 Taunton, J., Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

Formal Name	4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
Molecular Formula	C₁₅H₂₃N₃O₃
Formula Weight	293.4
Formulation	A crystalline solid
Purity	≥98%
λ_max	301 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ONC(=O)CCCCCNC(=O)c1ccc(cc1)N(C)C

Background Reading

Taunton, J., Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

Jung, M., Hoffmann, K., Brosch, G., et al. Analogues of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Bioorg Med Chem Lett 7 1655-1658 (1997).

CAY10398 is available in the following screening libraries:

Size	Global Purchasing
1 mg	See a distributor in your region for pricing
5 mg	See a distributor in your region for pricing
10 mg	See a distributor in your region for pricing
25 mg	See a distributor in your region for pricing

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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