Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10398 Exclusive

Cayman Chemical Item Number 89740

CAY10398

See more	Histone Deacetylase (12) Cancer (606)

Description

CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC₅₀ value of 10 µM.¹ Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.² However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC.

1 Jung, M., Hoffmann, K., Brosch, G., et al. Analogues of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Bioorg Med Chem Lett 7 1655-1658 (1997).

2 Taunton, J., Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

Formal Name	4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
Molecular Formula	C₁₅H₂₃N₃O₃
Formula Weight	293.4
Formulation	A crystalline solid
Purity	>98%
λ_max	301 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ONC(=O)CCCCCNC(=O)c1ccc(cc1)N(C)C

Background Reading

Taunton, J., Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

Jung, M., Hoffmann, K., Brosch, G., et al. Analogues of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Bioorg Med Chem Lett 7 1655-1658 (1997).

CAY10398 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$16.00		$0.00
5 mg	$72.00		$0.00
10 mg	$128.00		$0.00
25 mg	$280.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

SAHA

Suberohydroxamic Acid

Trichostatin A

Tubastatin A (trifluoroacetate salt) Exclusive

Show all 9 Hide all but first 3

Downloads

	Download Product Insert 115 Kb PDF
	Download Material Safety Data Sheet (MSDS) 84 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640