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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Carnosol

Cayman Chemical Item Number 89800

(CAS 5957-80-2)

Carnosol (CAS 5957-80-2)

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Description

Carnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis.1 The effective dose reported is 1-10 µM topically or 6 µg/ml when added to supernatants of cultured cells.2 Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-DNA adducts.1

1 Singletary, K., MacDonald, C., and Wallig, M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 104 43-48 (1996).

2 Chan, M.M., Ho, C.T., and Huang, H.I. Effects of three dietary phytochemicals from tea, rosemary, and turmeric on inflammation-induced nitrite production.. Cancer Lett 96 23-29 (1995).

Formal Name 1,​3,​4,​9,​10,​10aS-​hexahydro-​5,​6-​dihydroxy-​1,​1-​dimethyl-​7-​isopropyl-​2H-​9S,​4aR-​(epoxymethano)phenanthren-​12-​one
CAS Number 5957-80-2
Molecular Formula C20H26O4
Formula Weight 330.4
Formulation A crystalline solid
Purity >96%
λmax 212, 285 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC(C)​c1cc2C3OC(=O)​C4(CCCC(C)​(C)​C4C3)​c2c(O)​c1O

Background Reading

Singletary, K., MacDonald, C., and Wallig, M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 104 43-48 (1996).

Chan, M.M., Ho, C.T., and Huang, H.I. Effects of three dietary phytochemicals from tea, rosemary, and turmeric on inflammation-induced nitrite production.. Cancer Lett 96 23-29 (1995).

Carnosol is available in the following screening library:

Size Price Quantity Subtotal
1 mg $36.00 $0.00
5 mg $162.00 $0.00
10 mg $288.00 $0.00
50 mg $1,260.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-09. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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