13,14-dihydro-15-keto Prostaglandin E1-d4

13,14-dihydro-15-keto Prostaglandin E₁-d₄

Cayman Chemical Item Number 9000288

13,14-dh-15-k PGE₁-d₄

Description

13,14-dihydro-15-keto Prostaglandin E₁-d₄ (13,14-dh-15-k PGE₁-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE₁ by GC- or LC-mass spectrometry. 13,14-dh-15-k PGE₁ is a metabolite of PGE₁ with much reduced biological activity.^1,2,3 Steady state plasma concentrations are about 10 pg/ml.¹ 13,14-dh-15-k PGE₁ is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀ values of 54 and 200 µM, respectively, compared to PGE₁ which has an IC₅₀ value of 40 nM.⁴

1 Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E₁ and prostaglandin E₂ in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

2 Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E₁ and E₂ in man. J Biol Chem 246 6713-6721 (1971).

3 Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E₁ administered intravenously to human volunteers. J Physiol Pharmacol 42 327-331 (1991).

4 Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc Est Acad Sci Chem 40 179-180 (1991).

Synonyms

13,14-dh-15-k PGE1-d4

Formal Name

9,15-dioxo-11α-hydroxy-prostan-1-oic-3,3,4,4-d4 acid

Molecular Formula

C₂₀H₃₀O₅D₄

Formula Weight

358.5

Formulation

A solution in methyl acetate

Purity

≥99% deuterated product

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

Copy SMILES to clipboard

CCCCCC(=O)CC[C@H]1C(O)CC(=O)C1CCCCCCC(=O)O

Background Reading

Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E₁ and prostaglandin E₂ in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc Est Acad Sci Chem 40 179-180 (1991).

Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E₁ and E₂ in man. J Biol Chem 246 6713-6721 (1971).

Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E₁ administered intravenously to human volunteers. J Physiol Pharmacol 42 327-331 (1991).

Show all 4 Hide all but first 3

Size

Price

Quantity

Subtotal

25 µg 
$81.00

$0.00

50 µg 
$154.00

$0.00

100 µg 
$292.00

$0.00

1 mg 
$2,268.00

$0.00

Bulk
Contact

Cart Total

$0.00

Other Resources

Management Team Company Profile Company History ChemAssistant Tools FAQs

Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases

Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule

Order Terms Browser Recommendation Privacy Statement Site Map

13,14-dihydro-15-keto Prostaglandin E₁-d₄